PhD Student in Translational Cancer Research, SNSF project
Establish, characterise and maintain patient-derived cancer cell lines and 3D organoids, including models derived prospectively from fresh tumour biopsies Perform in vitro efficacy studies and mechanistic validation experiments, using drug response, clonogenic growth and live-cell imaging assays Design and carry out genome-wide CRISPR/Cas9 synthetic lethality screens and validate the resulting druggable hits Analyse screening and sequencing data using established bioinformatics pipelines (MAGeCK RRA/MLE, R) Perform confocal and multiplexed immunofluorescence microscopy Contribute to in vivo…
