PhD Student - DNA Break Signature in Cancers
The Junior Research Group " Brain Mosaicism and Tumorigenesis ", headed by Dr. Pei-Chi Wei, is seeking, starting at the earliest date possible, a Project Description: Replication stress (RS) disrupts DNA replication and is a hallmark of cancer. RS often leads to DNA double-strand breaks (DSBs), which can fuel genomic instability but also reveal therapeutic vulnerabilities. In collaboration with the Aqeilan Lab (Hebrew University of Jerusalem, Israel), we aim to map RS-mediated and naturally occurring DSBs in cancer cells at nucleotide resolution. Using advanced sequencing technologies, we…
